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Longhurst Lab, UC Irvine School of Medicine, Samueli Center

Research on Anti-Aging Compounds

Research in Dr. Mahtab Jafari's laboratory is focused on the anti-aging effects of a number of botanicals and pharmaceutical compounds. Developing sound and scientific methods has been the main challenge in our laboratory.

We need appropriate methodologies to study the pharmacology of aging in model species, if experimental findings with such systems are to be extrapolated to the treatment of human aging. While research on anti-aging compounds using the premier animal genetic systems, Drosophila melanogaster and Caenorhabditis elegans, has already started, the fundamental biological issues involved in such screening have not been systematically formulated.

In our laboratory, using the fruit fly (Drosophila) as our animal model, we have developed methodologies to study anti-aging compounds. Using these methods, we have evaluated a number of natural products and Chinese herbals with potential impact on longevity. Although the results obtained from our experiments should not be immediately extrapolated to humans, they help us narrow the library of compounds that could be considered for further testing in vertebrate animal models, such as mice, and eventually humans.

Recent Publications

Jafari M, Long AD, Mueller LD and Rose MR. Pharmacology of Aging in Drosophila. Drug Discovery. In Press.

Jafari M and Rose MR. 2005. Rules for the Use of Model Organisms in Anti-Aging Pharmacology. Aging Cell. In Press