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ZhiLing Guo

zhiling guo, susan samueli center for integrative medicine, uc irvine school of medicineAssociate Project Scientist, Department of Medicine, Susan Samueli Center for Integrative Medicine, School of Medicine

M.D., Tongji Medical University, Wuhan, China, 1986

Ph.D., Tongji Medical University, Wuhan, China, 1994, Cardiology

Phone: 949.824.8375
Fax: 949.824.2200

University of California
C240 Medical Sciences 1
Mail Code: 4075 Irvine, CA 92697

Research Interests
Cardiology, neuroscience, neuroanatomy, neurophysiology, acupuncture

Academic Distinctions
1994 Excellent graduate student with honors, Tongji Medical University, China 1995 Research award, Tongji Medical University, China
1996 Scientific research award, Hubei Province, China
1996 Excellent teacher with honors, Tongji Medical University, China
1998 - 2000 postdoctoral fellowship award sponsored by the American Heart Association, Western States Affiliate (AHA-WS)
1998 National research award in Chinese traditional medicine, the Administration Bureau of National Traditional Medicine, China
2001 - 2003 Beginning grant-in-aid award, AHA-WS
2003 - 2005 Beginning grant-in-aid award, AHA-WS
2005 - 2006 Faculty career development award for academic appointees, UC Irvine
2008 Travel Award to attend the Beijing Joint Conference of Physiological Sciences, the American Physiological Society

2007 – Present, Associate Project Scientist, Department of Medicine and Susan-Samueli Center for Integrative Medicine, UC Irvine

Research Abstract
I have been conducting two major research projects supported by the National Institutes of Health (NIH) and the American Heart association.The first study examines specific brain areas that respond to acupuncture through anatomical mapping of their early gene expressions. I am exploring direct anatomical relationships between brain regions activated by acupuncture and potential involvement of neural substances. This study will help us to understand activation of central neuropathways during applications of acupuncture.The second study looks at the central regulation of excitatory cardiovascular responses during myocardial ischemia (e.g., heart attack), including hypertensive responses and arrhythmias that result in significant patient mortality. Currently, I am studying mechanisms underlying the brain stem's role in processing these responses using anatomical, reflex and electrophysiological approaches. The aim of this study is to develop new methods to manage adverse cardiovascular responses during myocardial ischemia.

Selected Publications
1. Guo ZL, Lai HC, and Longhurst JC. Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat. Brain Res. 925: 55-66, 2002.

2. Guo ZL, Li P, and Longhurst JC. Central pathways in the pons and midbrain involved in cardiac sympathoexcitatory reflexes in cats. Neuroscience. 113: 435-447, 2002.

3. Guo ZL and Longhurst JC. Activation of nitric oxide-producing neurons in the brain stem during cardiac sympathoexcitatory reflexes in the cat. Neuroscience. 116: 167-178, 2003.

4. Guo ZL and Moazzami AR. Involvement of nuclei in the hypothalamus in cardiac sympathoexcitatory reflexes in cats. Brain Res. 1006:36-482, 2004.

5. Guo ZL, Moazzami AR, Longhurst JC. Electroacupuncture induces c-Fos expression in rostral ventrolateral medulla and periaqueductal gray in cats: relationship to opioid-containing neurons. Brain Res. 1030:103-115, 2004.

6. Guo ZL, Moazzami AR, and Longhurst JC. Stimulation of cardiac sympathetic afferents activates glutamatergic neurons in the parabrachial nucleus: relation to neurons containing nNOS. Brain Res. 1053:97-107, 2005.

7. Guo ZL and Longhurst JC. Responses of neurons containing VGLUT3/nNOS-cGMP in rVLM to cardiac stimulation. NeuroReport. 17:255-259, 2006.

8. Zhou W, Fu LW, Tjen-A-Looi SC, Guo ZL and Longhurst JC. Role of glutamate in a visceral sympathoexcitatory reflex in rostral ventrolateral medulla of cats. Am. J. Physiol. 291(Heart Circ. Physiol.): H1309-H1318, 2006.

9. Zhou W, Fu LW, Guo ZL and Longhurst JC. Role of glutamate in the rostral ventrolateral medulla in acupuncture-related modulation of visceral reflex sympathoexcitation. Am. J. Physiol. 292(Heart Circ. Physiol.): H1868-H1875, 2007.

10. Guo ZL and Longhurst JC. Expression of c-Fos in arcuate nucleus induced by electroacupuncture: Relations to neurons containing opioids and glutamate. Brain Res. 1166:65-76, 2007 (a figure was featured on the cover of this issue of the journal).

11. Fu LW, Guo ZL and Longhurst JC. Undiscovered role of endogenous TxA2 in activation of cardiac sympathetic afferents during ischemia. J. Physiol. 586:3287-300, 2008.

12. Guo ZL, Moazzami AR, Tjen-A-Looi SC and Longhurst JC. Responses of opioid and serotonin containing medullary raphe neurons to electroacupuncture. Brain Res. 1229:125-136, 2008.

13. Li P, Tjen-A-Looi SC, Guo ZL, Fu LW and Longhurst JC. Long-loop pathways in cardiovascular electroacupuncture responses. J. Appl. Physiol. 106:620-630, 2009.

14. Guo ZL, Tjen-A-Looi SC, Fu LW and Longhurst JC. Nitric oxide in rostral ventrolateral medulla regulates cardiac-sympathetic reflex: role of synthase isoforms. Am. J. Physiol. 297(Heart Circ. Physiol.): H1478-H1486, 2009.

Professional Societies
The American Association for the Advancement of Science
The American Physiological Society
The American Heart Association Society for Neuroscience

1. R01-HL63313; "CNS Autonomic Regulation by Electroacupuncture", (Co-investigator, 2009-2013).

2. R01-HL66217; “Mechanisms of Regulation of Cardiac Afferents”, (Co-investigator, 2006- 2010).

3. R01–HL72125; “Neural Substrates of Electroacupuncture in Cardiovascular Control”, (Co-investigator, 2003-2012).

Research Center: Samueli Center for Integrative Medicine

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